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中国人民解放军第三〇九医院神经外科
汤可
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（ACTH腺瘤概述）垂体腺瘤的诊断及其手术治疗
AdrenocorticotrophicHormone-SecretingPituitaryAdenomasAdenomasthatsecreteexcessadrenocorticotrophichormone(ACTH),therebyproducingsecondaryhypercortisolemia,resultintheclinicalsyndromeknownasCushing’sdisease.ThisdiagnosismustbedistinguishedfromCushing’ssyndrome,whichisthegeneralizedtermforeitheraniatrogenicorpathologicexcessofglucocorticoids.EctopicACTH-producingtumors,suchassmall-celllungcancer,bronchialcarcinoid,foregutcarcinoid,medullarycarcinomaofthethyroid,isletcelltumorsofthepancreas,pheochromocytoma,andspecificovariantumors,canalsoleadtoCushing’ssyndrome.Cushing’ssyndromeisalsoobservedinpatientswithcorticotropinreleasinghormone(CRH)-hypersecretingtumorssuchassmall-celllungcancer,nephroblastoma,medullarycarcinomaofthethyroid,prostaticcarcinoma,coloniccarcinoma,andbronchialcarcinoid.Non-neoplasticconditionsthatareassociatedwithlow-levelglucocorticoidexcessarealsoconsideredforthisdifferential,includingobesity,alcoholism,iatrogenicglucocorticoidingestion,depression,andchronicexposuretoastressfulstimulus.Cushing’sdiseaseisclinicallyindistinguishablefromCushing’ssyndrome.Thepatients’featureshaveaprominentcentripetalfatdeposition(primarilyintheface,supraclavicular,anddorsocervicalfatpads)andassociatedweightgain.Thecharacteristicfatdistributioninthefaceanddorsocervicalfatpadis北京中科白癜风医院诈骗曝光北京哪治白癜风
